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5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interactionwith eukaryotic initiation factor 4A-I

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 476-492 doi: 10.1007/s11684-022-0966-6

Abstract: tiRNA-Gln knockdown yielded opposite results. 5′-tiRNA-Gln exerted its function by binding eukaryotic initiationfactor 4A-I (EIF4A1), which unwinds complex RNA secondary structures during translation initiation,causing the partial inhibition of translation.intramolecular G-quadruplex structure is crucial for 5′-tiRNA-Gln to strongly bind EIF4A1 and repress translationmRNA binding through the intramolecular G-quadruplex structure, and this process partially inhibits translation

Keywords： EIF4A1     G-quadruplex     hepatocellular carcinoma     tRNA-derived small RNA     translation initiation    

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Progress in Machine Translation Review

Haifeng Wang,Hua Wu,Zhongjun He,Liang Huang,Kenneth Ward Church

Engineering 2022, Volume 18, Issue 11,   Pages 143-153 doi: 10.1016/j.eng.2021.03.023

Abstract: machine translation (NMT).In this article, we first review the history of machine translation from rule-based machine translationto example-based machine translation and statistical machine translation.translation quality and latency.We then describe various products and applications of machine translation.

Keywords： Machine translation     Neural machine translation     Simultaneous translation    

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Research on initiation network reliability of viaduct demolition blasting

Wu Xinxia,Zhao Gen,Xie Xianqi

Strategic Study of CAE 2014, Volume 16, Issue 11,   Pages 72-77

Abstract:

Non-electric initiation system was the onlyinitiation system for viaduct blasting demolition.>the relay point characteristicof multiple parallel detonator initiationReliability standard for non-electric initiationuplex-cross non-electric initiation

Keywords： viaduct     demolition blasting     initiation system     reliability    

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Liquid metal material genome: Initiation of a new research track towards discovery of advanced energy

Lei WANG, Jing LIU

Frontiers in Energy 2013, Volume 7, Issue 3,   Pages 317-332 doi: 10.1007/s11708-013-0271-9

Abstract: As the basis of modern industry, the roles materials play are becoming increasingly vital in this day and age. With many superior physical properties over conventional fluids, the low melting point liquid metal material, especially room-temperature liquid metal, is recently found to be uniquely useful in a wide variety of emerging areas from energy, electronics to medical sciences. However, with the coming enormous utilization of such materials, serious issues also arise which urgently need to be addressed. A biggest concern to impede the large scale application of room-temperature liquid metal technologies is that there is currently a strong shortage of the materials and species available to meet the tough requirements such as cost, melting point, electrical and thermal conductivity, etc. Inspired by the Material Genome Initiative as issued in 2011 by the United States of America, a more specific and focused project initiative was proposed in this paper—the liquid metal material genome aimed to discover advanced new functional alloys with low melting point so as to fulfill various increasing needs. The basic schemes and road map for this new research program, which is expected to have a worldwide significance, were outlined. The theoretical strategies and experimental methods in the research and development of liquid metal material genome were introduced. Particularly, the calculation of phase diagram (CALPHAD) approach as a highly effective way for material design was discussed. Further, the first-principles (FP) calculation was suggested to combine with the statistical thermodynamics to calculate the thermodynamic functions so as to enrich the CALPHAD database of liquid metals. When the experimental data are too scarce to perform a regular treatment, the combination of FP calculation, cluster variation method (CVM) or molecular dynamics (MD), and CALPHAD, referred to as the mixed FP-CVM-CALPHAD method can be a promising way to solve the problem. Except for the theoretical strategies, several parallel processing experimental methods were also analyzed, which can help improve the efficiency of finding new liquid metal materials and reducing the cost. The liquid metal material genome proposal as initiated in this paper will accelerate the process of finding and utilization of new functional materials.

Keywords： liquid metal material genome     energy material     material discovery     advanced material     room-temperature liquid alloy     thermodynamics     phase diagram    

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Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 33-40 doi: 10.1007/s11684-016-0431-5

Abstract: increasing number of recent studies have analyzed the contribution of cancer microenvironment to the initiationCAFs not only facilitate the initiation, growth, angiogenesis, invasion, and metastasis of cancer but

Keywords： cancer-associated fibroblast     breast cancer     progression     prognosis    

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Fatigue crack initiation of magnesium alloys under elastic stress amplitudes: A review

B. J. WANG, D. K. XU, S. D. WANG, E. H. HAN

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 1,   Pages 113-127 doi: 10.1007/s11465-018-0482-1

Abstract: Given their hexagonal close packed structure, the fatigue crack initiation of Mg and its alloys is closelyIn this paper, some fundamental aspects about the fatigue crack initiation mechanisms of Mg alloys arereviewed, including the 3 followings: 1) Fatigue crack initiation of as-cast Mg alloys, 2) influenceof microstructure on fatigue crack initiation of wrought Mg alloys, and 3) the effect of heat treatmenton fatigue initiation mechanisms.

Keywords： Mg alloys     fatigue behavior     microstructure     crack initiation     deformation mechanism    

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regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract: technologies, many newly reported genes that are recurrently mutated in AML have been found to govern the initiationwithout causing the full-blown leukemia, the function of this driver mutation appear to persist from AML initiation

Keywords： preleukemic stem cell     acute myeloid leukemia     relapse     DNMT3A    

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Incorporating target language semantic roles into a string-to-tree translation model Article

Chao SU, Yu-hang GUO, He-yan HUANG, Shu-min SHI, Chong FENG

Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 10,   Pages 1534-1542 doi: 10.1631/FITEE.1601349

Abstract: The string-to-tree model is one of the most successful syntax-based statistical machine translation (paper, we propose two methods to use semantic roles to improve the performance of the string-to-tree translationWe then perform string-to-tree machine translation using the newly generated trees.Our methods enable the system to train and choose better translation rules using semantic informationOur experiments showed significant improvements over the state-of-the-art string-to-tree translation

Keywords： Machine translation     Semantic role     Syntax tree     String-to-tree    

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Hierarchical approach for fatigue cracking performance evaluation in asphalt pavements

Ibrahim ONIFADE, Yared DINEGDAE, Björn BIRGISSON

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 3,   Pages 257-269 doi: 10.1007/s11709-017-0410-1

Abstract: In this paper, a hierarchical approach is proposed for the evaluation of fatigue cracking in asphalt concrete pavements considering three different levels of complexities in the representation of the material behaviour, design parameters characterization and the determination of the pavement response as well as damage computation. Based on the developed hierarchical approach, three damage computation levels are identified and proposed. The levels of fatigue damage analysis provides pavement engineers a variety of tools that can be used for pavement analysis depending on the availability of data, required level of prediction accuracy and computational power at their disposal. The hierarchical approach also provides a systematic approach for the understanding of the fundamental mechanisms of pavement deterioration, the elimination of the empiricism associated with pavement design today and the transition towards the use of sound principles of mechanics in pavement analysis and design.

Keywords： fatigue cracking     energy based     crack initiation     mechanistic approach     pavement analysis    

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Initiation and propagation laws of the glass cracks in specimens subjected to normal loading under the

WAN Zhen-ping, LIU Ya-jun, TANG Yong, YE Bang-yan

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 2,   Pages 194-198 doi: 10.1007/s11465-005-0011-x

Abstract: machining precision of part surfaces and to facilitate tool design and cutting parameter selection, the initiationResearch results show that initiation and propagation laws are the same with interior symmetric wedge

Keywords： different     30o-120o     relationship     initiation     cutting parameter    

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Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 276-284 doi: 10.1007/s11684-021-0855-4

Abstract: We demonstrated that chemotherapy initiation with single-course MTX may be an alternative regimen for

Keywords： gestational trophoblastic neoplasia (GTN)     methotrexate (MTX)     dactinomycin (ACTD)    

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Electronic Detonator Initiation Technology: Research Progress and Development Strategies

Leng Zhendong , Fan Yong , Tu Shufang , Zhou Guisong , Guo Yiming

Strategic Study of CAE 2023, Volume 25, Issue 1,   Pages 142-154 doi: 10.15302/J-SSCAE-2023.07.001

Abstract: "text-align: justify;">Electronic detonators not only improve delay accuracy and the flexibility of initiationThis study summarized the development status of the electronic detonator initiation technology fromelectronic detonators will develop toward serialization and standardization, the electronic detonator initiationelectronic detonator delay design theory will develop toward short delay, and the electronic detonator initiationprecise delay-controlled blasting, integration of information technology with electronic detonator initiation

Keywords： electronic detonator     initiation technology     delay timing     design theory     standard system    

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Initiation of Setaria as a model plant

Xianmin DIAO,James SCHNABLE,Jeffrey L. BENNETZEN,Jiayang LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1,   Pages 16-20 doi: 10.15302/J-FASE-2014011

Abstract: Model organisms such as Arabidopsis ( ) and rice ( ) have proven essential for efficient scientific discovery and development of new methods. With the diversity of plant lineages, some important processes such as C photosynthesis are not found in either Arabidopsis or rice, so new model species are needed. Due to their small diploid genomes, short life cycles, self-pollination, small adult statures and prolific seed production, domesticated foxtail millet ( ) and its wild ancestor, green foxtail ( ), have recently been proposed as novel model species for functional genomics of the Panicoideae, especially for study of C photosynthesis. This review outlines the development of these species as model organisms, and discusses current challenges and future potential of a Setaria model.

Keywords： Setaria     foxtail millet     C4 photosynthesis     model organism    

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Recent Progress in Cartilage Tissue Engineering—Our Experience and Future Directions

Yu Liu, Guangdong Zhou, Yilin Cao

Engineering 2017, Volume 3, Issue 1,   Pages 28-35 doi: 10.1016/J.ENG.2017.01.010

Abstract: The statuses of preclinical animal investigations and of the clinical translation of engineered cartilage

Keywords： Cartilage tissue engineering     Preclinical immunocompetent animal     investigation     Clinical translation     Orthopedic    

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Blasting Technologies of Decreasing Vibration in Subway Tunnel Underpass Adjacent Upper Buildings

Fang Junbo

Strategic Study of CAE 2014, Volume 16, Issue 11,   Pages 58-64

Abstract: insure the safety of the upper buildings, technologies of parallel cut with big empty hole, one-time initiationmeet large cross-section tunnel blasting excavation requirements, multiple cross-section can’t initiation

Keywords： blasting design     parallel cut     big empty hole     delay- time initiation     short- hole blasting    

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Title Author Date Type Operation

5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interactionwith eukaryotic initiation factor 4A-I

Journal Article

Progress in Machine Translation

Haifeng Wang,Hua Wu,Zhongjun He,Liang Huang,Kenneth Ward Church

Journal Article

Research on initiation network reliability of viaduct demolition blasting

Wu Xinxia,Zhao Gen,Xie Xianqi

Journal Article

Liquid metal material genome: Initiation of a new research track towards discovery of advanced energy

Lei WANG, Jing LIU

Journal Article

Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Journal Article

Fatigue crack initiation of magnesium alloys under elastic stress amplitudes: A review

B. J. WANG, D. K. XU, S. D. WANG, E. H. HAN

Journal Article

regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation

Yuting Tan,Han Liu,Saijuan Chen

Journal Article

Incorporating target language semantic roles into a string-to-tree translation model

Chao SU, Yu-hang GUO, He-yan HUANG, Shu-min SHI, Chong FENG

Journal Article

Hierarchical approach for fatigue cracking performance evaluation in asphalt pavements

Ibrahim ONIFADE, Yared DINEGDAE, Björn BIRGISSON

Journal Article

Initiation and propagation laws of the glass cracks in specimens subjected to normal loading under the

WAN Zhen-ping, LIU Ya-jun, TANG Yong, YE Bang-yan

Journal Article

Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course

Journal Article

Electronic Detonator Initiation Technology: Research Progress and Development Strategies

Leng Zhendong , Fan Yong , Tu Shufang , Zhou Guisong , Guo Yiming

Journal Article

Initiation of Setaria as a model plant

Xianmin DIAO,James SCHNABLE,Jeffrey L. BENNETZEN,Jiayang LI

Journal Article

Recent Progress in Cartilage Tissue Engineering—Our Experience and Future Directions

Yu Liu, Guangdong Zhou, Yilin Cao

Journal Article

Blasting Technologies of Decreasing Vibration in Subway Tunnel Underpass Adjacent Upper Buildings

Fang Junbo

Journal Article